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Description
ACLY/ATP citrate lyase Recombinant Rabbit mAb (S-2025-32)Product Specification Host Rabbit Antigen ACLY ATP citrate lyase Synonyms ATP citrate synthase; ATP citrate (pro S ) lyase (ACL); Citrate cleavage enzyme Immunogen Synthetic Peptide Location Cytoplasm Accession P53396 Clone Number S 2025 32 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P, ICC Reactivity Hu, Ms, Rt Positive Sample HeLa, MCF7, HepG2, Jurkat, 293T, NIH 3T3, mouse liver, C6, rat liver Predicted Reactivity Sh, Bv
Product Specification
| Host | Rabbit |
| Antigen | ACLY/ATP citrate lyase |
| Synonyms | ATP-citrate synthase; ATP-citrate (pro-S-)-lyase (ACL); Citrate cleavage enzyme |
| Immunogen | Synthetic Peptide |
| Location | Cytoplasm |
| Accession | P53396 |
| Clone Number | S-2025-32 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P, ICC |
| Reactivity | Hu, Ms, Rt |
| Positive Sample | HeLa, MCF7, HepG2, Jurkat, 293T, NIH/3T3, mouse liver, C6, rat liver |
| Predicted Reactivity | Sh, Bv |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000-1:5000 | Hu, Ms, Rt |
| IHC-P | 1:1000 | Hu, Ms, Rt |
| ICC | 1:500 | Hu |
Background
ACLY, also known as ATP citrate lyase, is a crucial enzyme involved in cellular metabolism. It catalyzes the conversion of citrate and ATP to oxaloacetate, acetyl-CoA, and ADP, playing a key role in linking glycolysis and lipid metabolism. ACLY is predominantly located in the cytoplasm and is essential for the production of acetyl-CoA, which serves as a vital precursor for fatty acid synthesis and cholesterol biosynthesis. Its activity is tightly regulated by various factors, including insulin and AMPK, reflecting its importance in maintaining metabolic homeostasis. Abnormal expression or activity of ACLY has been implicated in several diseases, such as cancer and metabolic disorders, making it an attractive target for therapeutic interventions.
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