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Description
HuR/ELAVL1 Recombinant Rabbit mAb (S-2357-20)Product Specification Host Rabbit Antigen HuR ELAVL1 Synonyms ELAV like protein 1; Hu antigen R (HuR) Immunogen Synthetic Peptide Location Cytoplasm, Nucleus Accession Q15717 Clone Number S 2357 20 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P, ICC Reactivity Hu, Ms, Rt Positive Sample HEK 293, Jurkat, MCF7, HeLa, RAW264. 7, rat brain Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical Appearance Liquid
Product Specification
| Host | Rabbit |
| Antigen | HuR/ELAVL1 |
| Synonyms | ELAV-like protein 1; Hu-antigen R (HuR) |
| Immunogen | Synthetic Peptide |
| Location | Cytoplasm, Nucleus |
| Accession | Q15717 |
| Clone Number | S-2357-20 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P, ICC |
| Reactivity | Hu, Ms, Rt |
| Positive Sample | HEK-293, Jurkat, MCF7, HeLa, RAW264.7, rat brain |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000-1:10000 | Hu, Ms, Rt |
| IHC-P | 1:1000 | Hu, Ms, Rt |
| ICC | 1:500 | Hu, Ms, Rt |
Background
HuR/ELAVL1 protein, also known as human antigen R, is a ubiquitously expressed RNA-binding protein encoded by the ELAVL1 gene. It is a member of the ELAV family of proteins and contains three RNA recognition motifs (RRMs) that enable it to bind to specific RNA sequences, particularly AU-rich elements (AREs) in the 3' untranslated regions (3'UTRs) of mRNAs. This binding stabilizes the mRNA, protecting it from degradation and enhancing its translation, thereby regulating gene expression. HuR plays crucial roles in various cellular processes, including cell differentiation, stress response, and tumorigenesis. Its dysregulation has been implicated in multiple diseases, such as cancer, cardiovascular diseases, and neurodegenerative disorders.
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