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Description
Human IGFBP5 Protein, hFC TagProduct Specification Species Human Synonyms Insulin like growth factor binding protein 5, IBP 5, IGF binding protein 5, IGFBP 5, IBP5 Accession P24593 Amino Acid Sequence Protein sequence (P24593, Leu21 Glu272, with C hFC tag)
Product Specification
| Species | Human |
| Synonyms | Insulin-like growth factor-binding protein 5, IBP-5, IGF-binding protein 5, IGFBP-5, IBP5 |
| Accession | P24593 |
| Amino Acid Sequence | Protein sequence (P24593, Leu21-Glu272, with C-hFC tag) LGSFVHCEPCDEKALSMCPPSPLGCELVKEPGCGCCMTCALAEGQSCGVYTERCAQGLRCLPRQDEEKPLHALLHGRGVCLNEKSYREQVKIERDSREHEEPTTSEMAEETYSPKIFRPKHTRISELKAEAVKKDRRKKLTQSKFVGGAENTAHPRIISAPEMRQESEQGPCRRHMEASLQELKASPRMVPRAVYLPNCDRKGFYKRKQCKPSRGRKRGICWCVDKYGMKLPGMEYVDGDFQCHTFDSSNVE |
| Expression System | HEK293 |
| Molecular Weight | Predicted MW: 54.6 kDa Observed MW: 30, 31, 33, 40, 70 kDa |
| Purity | ＞90% by SDS-PAGE |
| Endotoxin | <1EU/μg |
| Conjugation | Unconjugated |
| Physical Appearance | Lyophilized powder |
| Storage Buffer | Lyophilized from a 0.2 μm filtered solution of 0.2M PBS, pH7.4 with 3% trehalose. |
| Reconstitution | Reconstitute no more than 1 mg/mL according to the size in deionized water after rapid centrifugation. |
| Stability & Storage | 12 months from date of receipt, -20 to -70 °C as supplied. |
Background
Insulin-like growth factor-binding protein 5 (IGFBP5) is a key member of the IGFBP family, which regulates the bioavailability and activity of insulin-like growth factors (IGFs). Expressed in various tissues, IGFBP5 modulates cell proliferation, differentiation, and apoptosis through IGF-dependent and IGF-independent mechanisms. It interacts with extracellular matrix components and influences signaling pathways like MAPK and PI3K. IGFBP5 is implicated in physiological processes (e.g., bone development, wound healing) and pathologies, including cancer and fibrosis.
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