SKU: 24074861112

hnRNP U Recombinant Rabbit mAb (S-2375-23)

$90.00 $100.00
Save 10%
No.2 Bestseller on danzaybienestar.com >

Pay in installments of $25.00 with ShopPay, AfterPay and Klarna

Shipping Estimate
USA
  • USA
  • CAN

Ships within 48 hours · Estimated delivery Jul 18 - Jul 23

Promo Codes Available:

For Your Every Summer RSVP, with Code: SUMMER15

Description

hnRNP U Recombinant Rabbit mAb (S-2375-23)Product Specification Host Rabbit Antigen hnRNP U Synonyms Heterogeneous nuclear ribonucleoprotein U; GRIP120; Nuclear p120 ribonucleoprotein; Scaffold attachment factor A (SAF A); p120; pp120; C1orf199; HNRPU; SAFA; U21. 1; HNRNPU Immunogen Synthetic Peptide Location Cytoplasm, Nucleus Accession Q00839 Clone Number S 2375 23 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P Reactivity Hu, Ms, Rt, Mk Positive Sample HeLa, 293T, K562, NIH

Product Specification


Host Rabbit
Antigen hnRNP U
Synonyms Heterogeneous nuclear ribonucleoprotein U; GRIP120; Nuclear p120 ribonucleoprotein; Scaffold-attachment factor A (SAF-A); p120; pp120; C1orf199; HNRPU; SAFA; U21.1; HNRNPU
Immunogen Synthetic Peptide
Location Cytoplasm, Nucleus
Accession Q00839
Clone Number S-2375-23
Antibody Type Recombinant mAb
Isotype IgG
Application WB, IHC-P
Reactivity Hu, Ms, Rt, Mk
Positive Sample HeLa, 293T, K562, NIH/3T3, mouse liver, mouse brain, C6, rat brain, COS-7
Purification Protein A
Concentration 0.5 mg/ml
Conjugation Unconjugated
Physical Appearance Liquid
Storage Buffer

PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300
Stability & Storage

12 months from date of receipt / reconstitution, -20 °C as supplied

Dilution


application dilution species
WB 1:1000-1:50000 Hu, Ms, Rt, Mk
IHC-P 1:1000-1:5000 Hu, Ms, Rt

Background

Heterogeneous nuclear ribonucleoprotein U (HNRNPU, also called scaffold attachment factor A/SAF-A) is a ~120 kDa, ubiquitously expressed nuclear protein that functions as a multifunctional hub integrating RNA metabolism, chromatin organization and transcriptional control: it binds both RNA and AT-rich scaffold/matrix attachment region DNA through N-terminal SAP and C-terminal RGG RNA-binding domains to organize 3-D chromatin architecture, regulate alternative pre-mRNA splicing by controlling U2 snRNP maturation and Cajal body morphology, stabilize or destabilize specific mRNAs via 3′-UTR interactions, and modulate RNA polymerase II elongation together with cofactors like p300/PCAF; its actions are essential for heart development (cardiac-specific deletion causes lethal dilated cardiomyopathy with widespread splicing defects), early neuronal differentiation and brain function (mutations produce intellectual disability, autism spectrum disorder and epilepsy), and it also participates in X-chromosome inactivation, telomere maintenance and protein homeostasis by acting as a pseudosubstrate for SCF ubiquitin ligases[^8].

Shipping Notes
  • Free Standard Shipping on $100+ Orders to the USA.
  • Except Preorder products are shipped in 48 hours.
  • Delivery to the USA:
  1. Standard Shipping : 3-10 business days
  • If time is of the essence, please consider selecting expedited delivery for faster service.
Exchange/Return Notes
  • We offer a 30-day return/exchange service after receiving.
  • Final sale items are not eligible for returns or exchanges.
  • To process your return/exchange, please contact us at [email protected]
  • Please click here for more details>>> Return & Exchange Policy
SKU: 24074861112

Discover Niche Categories That Outsell

Top-Converting Item to Boost Your Average Order

4.1 ★★★★★
Based on 8 reviews
Sort
Highest Rating
Newest First
Oldest First
Product Reviews
H
Verified Purchase
How Family
Pawtucket, US
★★★★★ 5
Great reference for college US History I & Ii.
Format: Paperback
My college course references this book for US History I & Ii at Temple College in Texas.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on June 21, 2022
P
[email protected]
Natrona Heights, US
★★★★★ 4
A useful study
Format: Hardcover
This is a book that will make you angry. If you are a conservative, this book should make you feel very guilty. It is important to begin with that this book is a detour from Keyssar's larger project, which was supposed to be a history of the American working class' electoral participation. After struggling with the work for several years he realized that he needed to publish a whole book explaining what the right to vote actually was in American history. The result is a history of the slow and uneven path to universal suffrage in American history. We learn about the existence of the vote before 1776, the improvement that occured with the revolution, and the larger improvement that occured with the Jeffersonian/Jacksonian period in which the large majority of white men were able to vote. At the same time we learn of efforts to counter the expanding suffrage, such as disfranchisement of free blacks all over the country before 1861, attacks on the voting rights of paupers, felons, migrants and aliens, as well as the disfranchisment in the early 1800s of the limited voting rights women had in the early 1800s. Keyssar then goes on to discuss the narrowing of the portals from the 1860s to the 1920s, periods ironically bounded by giving the vote to blacks in the 1870s and to women by the 1920s. But in between that period nearly all blacks and many whites were disenfranchised in the south, while literacy, residence, nationality and registration systems sought to limit the vote in the North (while "asiatics" were barred in the west). The book concludes with the successful passage of the Voting Rights Act and the twenty-sixth amendment, but also with low turnout, an extremely narrow political spectrum, and government structures which limit political participation and reinforce conservative values. Much of this will not be new to historians, though never before has there been such detail and the twenty appendixes provided at the back will be invaluable for future reference. Sometimes Keyssar gives a qualititative estimate of how many Americans could vote (he suggests that perhaps 60% of white Americans could vote before 1776, a figure much lower than the 80-90% posited by more Panglossian historians). And there are many interesting details, such as the New York plan where registration was supposed to take place on Yom Kippur, conventiently leaving out many Jews. But otherwise the full results have been reserved for his upcoming work. This weakens his criticisms of American exceptionalism, since without a clear understanding of how much the vote declined in the North, we cannot see how fully the ponderous elitism of Parkman and Godkin were like the undemocratic aspects of German or Italian or even British liberalism. I am also do not agree with his description of slaves as a "peasantry." This implies that the majority of white farmers who were not slaveholders were a) not peasants and b) were otherwise indistinguishable on a class basis from the slaveholders. Recent southern agrarian history makes this assumption quite questionable. It is true that Americans were unenthusiatic as Europeans about the rise of the proletariat and rural subaltern classes, but it is insufficient to say that mass suffrage only occured because such classes were a small proportion of the population. They were also a small proportion of the population in France in 1848 and 1851 when universal male suffrage was declared, which did not prevent a greater degree of struggle over the question in that country. Enfranchising the majority of any population would raise serious issues of class domination and control regardless of the class structure. Nevertheless this is still a useful study, and reading the petty, racist, misogynist, self-serving and self-satisfied arguments against the suffrage will be a depressing experience. To think that such injustices could be continued for two centuries thanks to the endless cant of "state's rights" long after the republican content of that slogan had drained away will infuriate you.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on October 18, 2000
R
Verified Purchase
Randall Lindsey
Charlottesville, US
★★★★★ 5
Unfolding of the right to vote in the U.S.
In my forty years of studying the history of the U.S., I find this work to be the most authoritative and complete work yet encountered. Not only is the book a thorough guide through the evolution of our democracy, it is an entertaining read. The book is a 'must' read for those who seek a perspective on many of the current issues involving voting rights.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on November 4, 2006
J
Verified Purchase
Jj7484
Massapequa, US
★★★★★ 5
Typical for a casebook.
Format: Hardcover
I had to buy this for school. It’s overpriced and horrible to read but great for what I needed it for.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on June 29, 2019
C
Verified Purchase
C Cox
Cuba, US
★★★★★ 5
Good seller
Format: Hardcover
book in condition provided in description
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on April 7, 2021

recommand products

World's Greatest Licensed Vocational Nurse v1 - Vegan Leather Journal
29.95
Christmas Stained Glass Design 007 - Vegan Leather Journal
29.95
World's Greatest Kindergarten Special Education Teacher v1 - Vegan Leather Journal
29.95
Christmas Stained Glass Design 004 - Vegan Leather Journal
29.95
Christmas Stained Glass Design 031 - Vegan Leather Journal
29.95