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Description
Alexa Fluor® 488 Mouse Anti-Human CD41a Antibody (S-R554)Product Specification Host Mouse Antigen CD41a Synonyms Integrin alpha IIb; GPalpha IIb (GPIIb); Platelet membrane glycoprotein IIb; CD41; GP2B; ITGAB; ITGA2B Location Membrane Accession P08514 Clone Number S R554 Antibody Type Mouse mAb Isotype IgG1 Application FCM Reactivity Hu Positive Sample human peripheral blood platelets Purification Protein G Concentration 0. 2 mg ml Conjugation Alexa Fluor 488 Physical Appearance Liquid Storage Buffer PBS, 1%
Product Specification
| Host | Mouse |
| Antigen | CD41a |
| Synonyms | Integrin alpha-IIb; GPalpha IIb (GPIIb); Platelet membrane glycoprotein IIb; CD41; GP2B; ITGAB; ITGA2B |
| Location | Membrane |
| Accession | P08514 |
| Clone Number | S-R554 |
| Antibody Type | Mouse mAb |
| Isotype | IgG1 |
| Application | FCM |
| Reactivity | Hu |
| Positive Sample | human peripheral blood platelets |
| Purification | Protein G |
| Concentration | 0.2 mg/ml |
| Conjugation | Alexa Fluor® 488 |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 1% BSA, 0.3% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 5μl per million cells in 100μl volume | Hu |
Background
CD41a, also known as platelet glycoprotein IIb, is a crucial component of the GPIIb/IIIa complex on the platelet membrane. It is a calcium-dependent protein that pairs with CD61 to form the functional fibrinogen receptor, playing a vital role in platelet aggregation and blood clotting. This complex is primarily expressed in normal platelets and megakaryocytes. Additionally, CD41a is one of the first cell surface markers indicative of hematopoietic commitment and is involved in maintaining hematopoietic stem cell activity during embryonic development.
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