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Description
Sirt3 Recombinant Rabbit mAb (S-2004-6)Product Specification Host Rabbit Antigen Sirt3 Synonyms NAD dependent protein deacetylase sirtuin 3, mitochondrial; hSIRT3; NAD dependent protein delactylase sirtuin 3; Regulatory protein SIR2 homolog 3; SIR2 like protein 3; SIR2L3; SIRT3 Immunogen Synthetic Peptide Location Mitochondrion Accession Q9NTG7 Clone Number S 2004 6 Antibody Type Recombinant mAb Isotype IgG Application WB, ICC Reactivity Hu, Ms, Rt Positive Sample EK 293, PANC 1, mouse
Product Specification
| Host | Rabbit |
| Antigen | Sirt3 |
| Synonyms | NAD-dependent protein deacetylase sirtuin-3, mitochondrial; hSIRT3; NAD-dependent protein delactylase sirtuin-3; Regulatory protein SIR2 homolog 3; SIR2-like protein 3; SIR2L3; SIRT3 |
| Immunogen | Synthetic Peptide |
| Location | Mitochondrion |
| Accession | Q9NTG7 |
| Clone Number | S-2004-6 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, ICC |
| Reactivity | Hu, Ms, Rt |
| Positive Sample | EK-293, PANC-1, mouse liver, rat liver, HaCAT |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu, Ms, Rt |
| ICC | 1:100 | Hu |
Background
Sirt3, a member of the sirtuin family of proteins, is an important enzyme that is primarily located in the mitochondria. It functions as a deacetylase, removing acetyl groups from various proteins, which helps regulate their activity and stability. Sirt3 plays a crucial role in cellular metabolism, stress resistance, and aging processes. By modulating the activity of key metabolic enzymes, it helps maintain mitochondrial function and energy homeostasis. Additionally, Sirt3 is involved in protecting cells against oxidative stress by influencing the expression and activity of antioxidant enzymes. Its dysregulation has been implicated in various diseases, including metabolic disorders and cancer, making it a potential target for therapeutic interventions.
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